ParkinsonCanadaV1, Main, Exploration, bibRecord, 001492

The association between cognitive impairment and neuropsychiatric symptoms in patients with Parkinson's disease dementia

Identifieur interne : 001492 ( Main/Exploration ); précédent : 001491; suivant : 001493

The association between cognitive impairment and neuropsychiatric symptoms in patients with Parkinson's disease dementia

Auteurs : Wei-Ju Lee [Taïwan] ; Chia-Fen Tsai [Taïwan] ; Serge Gauthier [Canada] ; Shuu-Jiun Wang [Taïwan] ; Jong-Ling Fuh [Taïwan]

Source :

International psychogeriatrics [ 1041-6102 ] ; 2012.

RBID : Pascal:12-0453703

Descripteurs français

Pascal (Inist)
- Trouble cognitif, Trouble psychiatrique, Neuropsychiatrie, Symptomatologie, Maladie de Parkinson, Démence, Cognition, Analyse factorielle, Homme, Personne âgée.
Wicri :
- topic : Homme, Personne âgée.

English descriptors

KwdEn :
- Cognition, Cognitive disorder, Dementia, Elderly, Factor analysis, Human, Mental disorder, Neuropsychiatry, Parkinson disease, Symptomatology.

Abstract

Background: Neuropsychiatric symptoms (NPS) are common in patients with dementia associated with Parkinson's disease (PDD). The relationship between cognition and NPS in PDD has not been well studied. Methods: Patients diagnosed with PDD were assessed for cognitive function and NPS. The instruments used were the Neuropsychiatric Inventory (NPI), Mini-Mental State Examination (MMSE), and semantic verbal fluency according to the recommendation of the Movement Disorder Society Task Force. Results: We evaluated 127 PDD patients (76 males/51 females; mean age 77 ± 6.3 years). Their mean MMSE score was 17 ±6.5 and the mean NPI score was 19 ± 20.4. The most prevalent NPI items were anxiety (57.5%), sleep problems (53.5%), and apathy (52.0%). Principal component factor analysis revealed that 12 items formed three factors, namely "mood and psychosis" (delusion, hallucination, agitation, depression, anxiety, apathy, and irritability), "vegetative" (sleep and appetite problems), and "frontal" (euphoria, disinhibition, and aberrant motor behavior). Symptoms of hallucination were significantly associated with MMSE score, even after controlling for the confounding variables. Conclusion: NPS are common and diverse among patients with PDD. Three specific subgroups of NPS were identified. Hallucination was significantly correlated with cognitive impairment, and could be a predictor of cognition in PDD patients.

Affiliations:

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Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cognition</term>
<term>Cognitive disorder</term>
<term>Dementia</term>
<term>Elderly</term>
<term>Factor analysis</term>
<term>Human</term>
<term>Mental disorder</term>
<term>Neuropsychiatry</term>
<term>Parkinson disease</term>
<term>Symptomatology</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Trouble cognitif</term>
<term>Trouble psychiatrique</term>
<term>Neuropsychiatrie</term>
<term>Symptomatologie</term>
<term>Maladie de Parkinson</term>
<term>Démence</term>
<term>Cognition</term>
<term>Analyse factorielle</term>
<term>Homme</term>
<term>Personne âgée</term>
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<front><div type="abstract" xml:lang="en">Background: Neuropsychiatric symptoms (NPS) are common in patients with dementia associated with Parkinson's disease (PDD). The relationship between cognition and NPS in PDD has not been well studied. Methods: Patients diagnosed with PDD were assessed for cognitive function and NPS. The instruments used were the Neuropsychiatric Inventory (NPI), Mini-Mental State Examination (MMSE), and semantic verbal fluency according to the recommendation of the Movement Disorder Society Task Force. Results: We evaluated 127 PDD patients (76 males/51 females; mean age 77 ± 6.3 years). Their mean MMSE score was 17 ±6.5 and the mean NPI score was 19 ± 20.4. The most prevalent NPI items were anxiety (57.5%), sleep problems (53.5%), and apathy (52.0%). Principal component factor analysis revealed that 12 items formed three factors, namely "mood and psychosis" (delusion, hallucination, agitation, depression, anxiety, apathy, and irritability), "vegetative" (sleep and appetite problems), and "frontal" (euphoria, disinhibition, and aberrant motor behavior). Symptoms of hallucination were significantly associated with MMSE score, even after controlling for the confounding variables. Conclusion: NPS are common and diverse among patients with PDD. Three specific subgroups of NPS were identified. Hallucination was significantly correlated with cognitive impairment, and could be a predictor of cognition in PDD patients.</div>
</front>
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<name sortKey="Fuh, Jong Ling" sort="Fuh, Jong Ling" uniqKey="Fuh J" first="Jong-Ling" last="Fuh">Jong-Ling Fuh</name>
<name sortKey="Lee, Wei Ju" sort="Lee, Wei Ju" uniqKey="Lee W" first="Wei-Ju" last="Lee">Wei-Ju Lee</name>
<name sortKey="Lee, Wei Ju" sort="Lee, Wei Ju" uniqKey="Lee W" first="Wei-Ju" last="Lee">Wei-Ju Lee</name>
<name sortKey="Tsai, Chia Fen" sort="Tsai, Chia Fen" uniqKey="Tsai C" first="Chia-Fen" last="Tsai">Chia-Fen Tsai</name>
<name sortKey="Tsai, Chia Fen" sort="Tsai, Chia Fen" uniqKey="Tsai C" first="Chia-Fen" last="Tsai">Chia-Fen Tsai</name>
<name sortKey="Tsai, Chia Fen" sort="Tsai, Chia Fen" uniqKey="Tsai C" first="Chia-Fen" last="Tsai">Chia-Fen Tsai</name>
<name sortKey="Wang, Shuu Jiun" sort="Wang, Shuu Jiun" uniqKey="Wang S" first="Shuu-Jiun" last="Wang">Shuu-Jiun Wang</name>
<name sortKey="Wang, Shuu Jiun" sort="Wang, Shuu Jiun" uniqKey="Wang S" first="Shuu-Jiun" last="Wang">Shuu-Jiun Wang</name>
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<country name="Canada"><region name="Québec"><name sortKey="Gauthier, Serge" sort="Gauthier, Serge" uniqKey="Gauthier S" first="Serge" last="Gauthier">Serge Gauthier</name>
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	La maladie de Parkinson au Canada (serveur d'exploration)
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La maladie de Parkinson au Canada (serveur d'exploration)

The association between cognitive impairment and neuropsychiatric symptoms in patients with Parkinson's disease dementia

The association between cognitive impairment and neuropsychiatric symptoms in patients with Parkinson's disease dementia

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri